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Smallwood s Piano Tutor William Smallwood tells the story of a boy growing up with the gift of music .Antinociceptive action of a cyclohexylamine derivative, DL-propyl-2-(1-oxopyrrolidin-2-yl)propylamine, in mice.
DL-Propyl-2-(1-oxopyrrolidin-2-yl)propylamine (KF-15393) was examined for its antinociceptive effect in mice using the tail-flick test and the hot-plate test. In the tail-flick test, KF-15393 (3, 10, 30, 100 mg/kg, s.c.) was injected into mice 15 min before the testing, and the tail-flick latencies were measured. In the hot-plate test, the reaction time of mice in pain was measured at an ambient temperature of 52 degrees C, and KF-15393 (0.3, 1, 3, 10 mg/kg, s.c.) was administered 15 min before the testing. The tail-flick and hot-plate tests were also carried out using morphine (3, 10, 30 mg/kg, s.c.), the opioid agonist, and morphine (3, 10 mg/kg, s.c.) + naloxone (1 mg/kg, s.c.), the opioid antagonist. The antinociceptive effect of KF-15393 in the tail-flick test was antagonized by naloxone, and KF-15393 (10 mg/kg, s.c.) alone had a significant effect in the hot-plate test. The antinociceptive effect of KF-15393 in both tests was significantly greater than that of morphine (10, 30 mg/kg, s.c.), but was almost similar to that of naloxone (1 mg/kg, s.c.). These results suggest that KF- 0b46394aab